This applies to the so-called intellectual in today's world. They are the ones who decide they can explain things without God. They are the college professors, the scientists, the philosophers, and all who see themselves as wise. They should enjoy this deceptive self-image while they can, because they will soon be faced with the truth that they are fools. There will be no escape.
"Thus saith the Lord God; Woe unto the foolish prophets, that follow their own spirit, and have seen nothing!" Ezekiel 13:3
Even theologians, ministers and pious lay people are fools if they follow their own 'wisdom' instead of God's Word. Their 'wisdom' is even a sham ... self-deception. Wisdom cannot be had without the Lord:
"The fear of the LORD is the beginning of wisdom: a good understanding have all they that do his commandments: his praise endureth for ever." Psalm 111:9
Jesus even rebuked those he loved because of their lack of understanding the prophecies and why he went to the cross. "Then he said unto them, O fools, and slow of heart to believe all that the prophets have spoken: Ought not Christ to have suffered these things, and to enter into his glory?" Luke 24.
Each of us can choose to be either a fool or one of the wise. It's clear-cut.